Pna oligomers conjugated to bacteria penetrating peptides bpps such as kff3k targeting essential bacterial genes such as acpp can inhibit bacterial growth at one digit micromolar concentrations it has been found that the lps of the outer membrane of gram negative bacteria is a barrier for cellular uptake of kff3k eg1 pna and that the sbma transporter protein is involved in the . The molecular backgrounds of these d negative phenotypes are beginning to emerge in 2 caucasians expressing the dce phenotype 1 had an in frame stop codon in exon 1 of the rhdgene70 and the other a deletion of 4 nucleotides in exon 4149 very recently the molecular basis of the major silent rhd allele namedrhd found in persons of african
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